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One is stomach acid it splits food and B12 apart, allowing the vitamin to bind to the salivas R-protein

When you have MTHFR gene mutations you lack the enzymes responsible for the conversion of folate that you eat into the active form 5-Methyltetrahydrofolate

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Dimpfel W, Suter A

[6] Conclusion The shift from conventional beverages to functional beverage development highlights growing consumer interest in health, wellness, and preventive nutrition