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There is currently no strong evidence suggesting that BPC-157 directly causes weight gain

In reality, starting high increases side effects, makes it impossible to identify your true minimum effective dose, and may actually reduce effectiveness if receptor downregulation occurs

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However, organotypic cultures of human tissue obtained after surgery on epileptic patients have been used to study neuronal and seizure activity, and BBB studies could clearly be envisaged (Le Duigou et al., Which Cell Types Are Optimal to Model BBB

More study results are expected in 2026, and it could potentially be approved as early as 2027