Increased ratio of Phylum Firmicutes / Bacteroidetes is usually considered to be associated with obesity-associated dysbiosis ( Firmicutes and Bacteroidetes , as well as levels of several bacteria associated with a pro-inflammatory state ( Bacteroidetes , and increased levels of Bifidobacterium spp., Anaerostipes spp., Enterococcus faecalis , and Lactobacillus spp ( Phascolarctobacterium , Blautia , Akkermansia , Ruminococcus , and the family Lachnospiraceae , which are also responsible for SCFAs production ( Table 2
The appetite-suppressing effects mediated through central nervous system pathways may also diminish, potentially leading to increased hunger and food intake
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TRIUMPH-1 (NCT05929066) will look at the efficacy and safety of retatrutide in people with overweight/obesity without T2D and will include subsets of participants with knee osteoarthritis (OA) or OSA