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This M1 reprogramming decreases the immune-tolerant environment within tumors, reducing tumor progression and potentially enhancing the efficacy of immunotherapies

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Clinically Down syndrome is manifested by hypothyroidism, malformation of the cardiac system and gastrointestinal tract, abnormal hearing and vision, and aberrant development of the brain resulting in severe intellectual disability

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Nature 531 , 651655 (2016)

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