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Some studies suggest that NSAIDs can interfere with mitochondrial function, leading to an increase in reactive oxygen species (ROS)unstable molecules that contribute to oxidative stress

Science 176 , 309310 (1972)

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Strikingly, higher SFB levels, as observed in MyD88 (an adaptor for different innate immune receptors which recognize microbial stimuli)-deficient mice models, protect mice of a diabetic genotype from the development of the disease, showing that the microbiota can exert both inhibiting and promoting effects [10]