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Additionally, it has been demonstrated that most genes involved in ferroptosis are directly or indirectly regulated by Nrf2 ( 5 Treating depression by inhibiting ferroptosis 5.1 Traditional Chinese medicine 5.1.1 Active ingredients of traditional Chinese medicine Allicin, a prominent active compound in Chinese herbal garlic, has been found to possess neuroprotective effects ( Saikosaponin B2 (SSB2), derived from the Chinese herbal medicine Radix Bupleuri, has a long history of being used to treat depression, as documented in the TCM classic Taiping Huimin HeJiJu Fang (YANG et al., 2017)

doi: 10.1186/ar3685 39 van KuijkAWVergunstCEGerlagDMBresnihanBGomez-ReinoJJRouzierRet al