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Future investigations should aim for larger, more demographically diverse sample cohorts to better understand the health benefits of this affordable and readily available ingredient

24 There have been reports that phenolics also inhibit the expression of both HMG-CoA reductase, involved in the regulation of cholesterol biosynthesis, and sterol regulatory element-binding protein-2, which triggers HMG-CoA for cholesterol biosynthesis in the liver

A total of 24 countries contributed to the publications included in this study

Zaharuddin ND, Noordin MI, Kadivar A

It is therefore not surprising that, based on the premise that the cumulative effect of subtle variations in key genes or regulatory pathways contributes to disease vulnerability (Boyle et al., 2017), risk must be estimated through a polygenic risk score