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NAC is generally considered safe when taken as directed

Ethics declarations Competing interests The authors declare no competing interests

Recent research has shown that hyperglycemia induced cellular stress, such as ERS (120) and oxidative stress (119), which stimulate the pyroptotic process in renal cells, and various signaling pathways, such as TLRs/NF-B/NLRP3 inflammasome signalling pathway, TXNIP/NLRP3 inflammasome pathway, ATP/P2X purinergic signalling pathway, and MAPKs/NLRP3 inflammasome signalling pathway (119, 121)

Perez-Miller, S

[DOI] [PubMed] [Google Scholar] 77.Jing X., Shi H., Zhang C., Ren M., Han M., Wei X., Zhang X., Lou H