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5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), the cytosolic enzyme that methylates nicotinamide to 1-methylnicotinamide (1-MNA) using S-adenosyl-L-methionine (SAM) as the methyl donor
Here are some general guidelines: Mild Deficiency: For those with a mild deficiency, a typical dosage might be 1,000 micrograms (mcg) once a week for several weeks
Food and Drug Administration (2024) 2
Unlike oral supplements, which must pass through the digestive system, injections provide direct delivery into the bloodstream
Some patients, particularly those with neurological involvement, may benefit from more frequent dosing (every 2 months rather than 3 months), but this should be medically supervised rather than self-adjusted
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