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The common side effects of semaglutide include nausea, diarrhea, vomiting, abdominal pain, constipation, and headache

Semaglutides effect on gastric emptying represents one of the most clinically significant mechanisms for potential drug interactions

While side effects such as nausea and gastrointestinal discomfort can occur, they typically subside over time

Whilst cardiometabolic risk factors were included as secondary endpoints, providing information on the potential impact of cardiovascular factors, these studies are not designed to assess this impact

However, pemvidutide showed a NASH reduction signal (reduction in liver fat) in an earlier Phase 1b trial interim analysis