According to the authors, boosting GSH status beneficially upregulates the genes of VD metabolism and VDR, both of which are needed to increase the bioavailability and blood levels of 25(OH)VD and reduce inflammation levels. They also found that co-supplementation with vitamin D and L-cysteine resulted in the upregulation of vitamin D regulatory genes and boosted vitamin D levels in the blood, as well as reduced inflammation and insulin resistance each with higher success compared to supplementing with vitamin D alone
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Some combine it with vitamin C and other antioxidants
2023;33:R915
Funding for the study was provided by the National Institutes of Health, the National Heart, Lung, and Blood Institute of the NIH, the Northwestern University Pulmonary and Critical Care Division Cugell Predoctoral Fellowship, the Cellular and Molecular Basis of Disease, the NRSA Training Program in Signal Transduction and Cancer, the Glenn Foundation for Medical Research Postdoctoral Fellowship in Aging Research, the Schmidt Science Fellows, in partnership with Rhodes Trust, the Simpson Querrey Fellowship in Data Science, the Training Program in Lung Sciences, the Medical Sciences Training Program and the Stand Up 2 Cancer Convergence 3.1416.
