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GLP-1 medications may also affect other aspects of eye health, according to a 2025 study in JAMA Network

The analysis revealed that members who remained in the program and continued their medication lost an average of 18.4% of their weight, significantly surpassing the 11.9% loss found in other real-world evidence

Changes in the phosphoproteome depend on functional selectivity and location bias In light of the location bias that was observed for the small molecule relative to peptide agonists of GLP-1R, we sought to examine the functional consequences of differences in intracellular signal transduction by phosphoproteomics

In order to clone the GLP-1 receptor Thorens drew on the expertise that he had picked up from cloning the GLUT2 gene which encodes for a protein that helps to transport glucose across cell membranes

Although fenfluramine and dexfenfluramine were withdrawn due to safety concerns, phentermine as monotherapy was considered safe and was not withdrawn from the market