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PT-141 activation of mPOA neurons appears to initiate downstream signaling cascades that: Enhance processing of sexual stimuli and context Increase neural responsiveness to arousal cues Facilitate coordination of sexual behavior patterns Modulate autonomic and endocrine responses Dopaminergic System Interactions Evidence from animal studies suggests PT-141s effects may involve modulation of dopamine signaling in brain regions controlling sexual function

doi: 10.1111/j.1365-2982.2011.01796.x 105