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At that point, tissue-level GHK-Cu has likely returned to baseline, and the cumulative signaling advantage of the loading phase is largely lost

People with acne-prone skin, enlarged pores, or history of blackheads and whiteheads are more likely to purge

Some clients notice changes within a few weeks, but more significant results often appear after several weeks to a few months of consistent treatment

Low-fat areas such as the inner thigh, the lower abdomen in leaner individuals, and sites near bony prominences should be avoided where possible as they offer less tissue cushioning and produce more pronounced discomfort

They also have an impact on NAMPT levels 6 , which fluctuate to meet cellular NAD+ demand