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Based on the various types and complexities involved, its management and evaluation become quite challenging

Florin TH, Woods HJ

Through its damaging effects on sperm DNA, membranes, and mitochondrial function, elevated levels of ROS compromise reproductive potential in both clinical and subclinical populations

A large international, multicenter, double-blind, placebo-controlled trial, the Folic Acid Clinical Trial (FACT), was initiated to evaluate whether high-dose folic acid supplementation throughout pregnancy could prevent preeclampsia and other adverse outcomes (e.g., maternal death, placental abruption, preterm delivery) (76)