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For the pulsatile peptides (sermorelin, CJC-1295 without DAC, ipamorelin), dosing on an empty stomach matters, because food, particularly carbohydrates and fats, can blunt the growth hormone response

References Anderson, J.M., et al

Transdermal patches Transdermal delivery systems using microneedles or permeation enhancers show promise for peptide delivery

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Psychiatric Effects In addition to physical complications, some patients have reported psychiatric side effects such as depression, anxiety, and suicidal thoughts after taking GLP-1 weight loss medications