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Creatine is necessary for all muscular function, and thus supports normal functioning of the heart and circulatory system

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While it is known that B-vitamin supplementation effectively treats hyperhomocysteinemia, there is a need for well-designed, large trials to evaluate the effect of B-vitamin supplementation on long-term outcomes, such as age-related cognitive decline and the incidence of Alzheimers disease

These side effects are typically minor and short-lived

By sticking to this detailed treatment plan, doctors can manage severe Vitamin B12 deficiency well