GLP-1RAs exert multiple anti-atherosclerotic effects contributing to stroke prevention such as enhanced plaque stability, reduced vascular smooth muscle proliferation, increased nitric oxide, and improved endothelial function
Bacteriostatic water maintains preservative efficacy for up to 28 days after first puncture when stored at 2-8C
however, the long-term safety profile remains undefined
Given that this is an investigational treatment, clinical trials are necessary to evaluate the efficacy and safety of the long-acting PYY analog, as indicated by the forthcoming Phase 1 SAD/MAD data expected in 2025
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