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Incubation with 100 nM semaglutide induced p-CREB expression in all nuclei, a response inhibited by coincubation with 1000 nM exendin 9-39, indicating that semaglutide binds to and activates GLP-1Rs on tanycytes

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PlexusDx recommends consulting a prescribing provider about whether dual GLP-1/GIP therapy (via GLP-Squared) or a single GLP-1 agent might achieve your weight loss goals with a more favorable risk-benefit profile