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This paper reviews the teratogenicity of isotretinoin in regard to aspects of species variation, toxicokinetics, and metabolism

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Bile Acid Metabolism Bile acids are not only crucial for dietary lipid digestion but also serve as important signaling molecules involved in the regulation of glucose and energy homeostasis via nuclear and membrane receptors such as farnesoid X receptor (FXR) and Takeda G-protein-coupled receptor 5 (TGR5)

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Full evaluation of an AHK-Cu protocol requires at least six months, preferably a year