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Of the 48 inter-molecular NOE restraints, only 2 NOEs could be assigned unambiguously and correspond to contacts between p53-Trp53 HE# - FOXO4-Leu160 HD# and p53-Trp53 HD#FOXO4-Leu109 HD# (Supplementary Note 1)

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Similar content being viewed by others Introduction Chronic obstructive pulmonary disease (COPD), a leading cause of morbidity and mortality worldwide [1], is characterized by persistent respiratory symptoms, such as cough, sputum production, and dyspnea [2]

Additionally, hospitals tend to handle patients with comorbidities such as diabetes and cardiovascular conditions, where GLP-1 drugs provide dual benefits, further driving their use in this setting