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Supporting this, ERK1 and ERK2 are overexpressed in leiomyoma as compared to the normal myometrium (Yu et al., 2008)

A double-blind, placebo-controlled pilot study involving 26 healthy elderly subjects revealed that participants who received 1 mg of melatonin nightly for four weeks showed improved performance on the California Verbal Learning Test-interference subtest compared to those who received a placebo [221]

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Alternative biomarkers might also include imaging, physiology and clinical data that reflect an underlying pathophysiological process that could be responsive to therapy