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Taking vitamin B12 along with vitamin C can reduce the amount of vitamin B12 available in the body

None of this means supplementation "doesn't work" for these groups it means the realistic timeline may sit toward the longer end of the 8-12 week range, or occasionally extend a few weeks beyond it, rather than indicating product failure

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Green et al 26 Severe clinical abnormalities should be treated intensively with B 12 , cyanoB 12 or hydroxyB 12 : HydroxyB 12 is commonly used in Europe, often at intervals of 23 months, as it seems to have better retention than cyanoB 12