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DXN-induced chemobrain is known to result in significant changes in oxidative stress biomarkers in the brain, including elevated levels of ROS, lipid peroxidation, and MDA, and reduction in endogenous antioxidants such as SOD and GPx as well as mitochondrial function ( The mortality rate serves as a vital metric in evaluating the risk associated with drug toxicity

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1 The most common adverse event leading to discontinuation was gastrointestinal disorders, occurring in 10% of patients in the Wegovy group and 2% in the placebo group

The studies Ive seen say that patients tend to plateau with semaglutide at 60 weeks

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