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The coordinates of individual subunits from the following previously reported structures were rigid-body fitted into the cryo-EM reconstruction with UCSF chimera: DDB1-DDA1 (PDB ID: 6DSZ), Ube2e2 (PDB ID: 6W9A), DET1 (Alphafold model: AF-Q7L5Y6-F1

Upon its accumulation and phosphorylation, HIF-1 dimerizes with HIF- (constitutively expressed nuclear proteins), enters the nucleus, and promotes the transcription of hypoxia response elements (HRE)-containing target genes involved in energy metabolism, erythropoiesis, vascular remodelling, and other processes (Fig

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Cetuximab promotes RSL3-induced ferroptosis by suppressing the Nrf2/HO-1 signalling pathway in KRAS mutant colorectal cancer

Each one has a specific job, but theyre designed to work together perfectly