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As of February 18, 2026, the class has expanded with established agents like semaglutide, liraglutide, dulaglutide, and exenatide, alongside dual GLP-1/GIP agonists such as tirzepatide, which are often discussed in GLP-1 contexts due to overlapping mechanisms and indications

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Conventional weight loss approaches are primarily caloric restriction, but GLP-1 mimetics offer a new pharmacological strategy that addresses the neuroendocrine mechanisms underlying obesity