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These nucleation substrates are commonly associated with joint microinjury or chronic inflammation, which helps explain the predilection of gouty arthritis for weight-bearing or structurally vulnerable joints ( 3 Crystal formation and growth stage: nucleation, growth, and aggregation of sodium urate crystals 3.1 Nucleation kinetics and crystal morphology of sodium urate crystals MSU crystal formation begins with nucleation within supersaturated solutions and is influenced by both classical and non-classical nucleation theories