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Supplementary Figure 8 (A, B) Cumulative data showing relative concentrations of decreased metabolites in the R vs A group

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Furthermore, many researchers have found that reduced GSH levels and GSH-dependent antioxidant enzyme activity in damaged myocardium due to excess ROS and disruption of the GSH synthesis process, along with increased oxidative damage and ferroptosis

There was also a 3-fold reduction in IL-10 after L-GSH supplementation in every category when compared to the control category before L-GSH supplementation ( Figure 7B )

2016;10, Reznikov LR, Grillo CA, Piroli GG, Pasumarthi RK, Reagan LP, Fadel J