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GLP-1 receptor agonists such as semaglutide and the dual GIP/GLP-1 agonist tirzepatide act on appetite, satiety, and gastric emptying, with evidence from programs like STEP (NEJM, 2021), SURMOUNT (NEJM, 2022), and SURMOUNT-OSA (NEJM, 2024)
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Trabalhos recentes sugerem uma interao com a via JAK-2/STAT-3, envolvida na resposta inflamatria e na sobrevivncia celular, reforando a hiptese de um mecanismo de ao pleiotrpico
Alpha-melanocyte-stimulating hormone protects against renal injury after ischemia in mice and rats
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