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Several of the proteins identified in STEP 1 and STEP 2 are known to be related to obesity and T2D pathophysiology and their associated complications, including C-reactive protein (CRP), adipokines (leptin, adiponectin), ghrelin, insulin-like growth factor binding protein (IGFBP), growth hormone receptor (GHR), neural cell adhesion molecule 1 (NCAM1) and netrin receptor (UNC5D), among others

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Remarkably, this proinflammatory ATM polarization phenotype was also observed in PAR2-R38E when compared with PAR2-WT mice (Figure 4B and Supplemental Figure 6B)

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