TNF- increases mucin secretion through the production of nitric oxide and cyclic-di-GMP, induction of the NF-B pathway, and goblet cell metaplasia in mice (Fischer et al., 1999
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Fatty acid carbon is essential for dNTP synthesis in endothelial cells (vol 520, pg 192, 2015)
Liraglutide, semaglutide and tirzepatide are incretin-based therapies currently approved by FDA for the management of obesity, while triple GIPR/GCGR/GLP-1R agonist retatrutide (LY3437943), the cagrilintide/semaglutide (CagriSema) 2.4 mg combination, high-dose oral semaglutide, and oral orforglipron are in advanced stages of development
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