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In other words, the high levels of glucaric acid in the aqueous humor may result from stimulation by elevated IOP

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Poly(ADP-ribose) polymerase inhibition as a novel therapeutic approach against intraepidermal nerve fiber loss and neuropathic pain associated with advanced diabetic neuropathy: a commentary on PARP Inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy

There is increasing evidence that microglia are key components in ALS motor neuron degeneration [25, 117, 118]