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491 Patients who received 200 mg of mirikizumab subcutaneously every 4 or 12 weeks presented a significant downward trend in the expression of genes encoding inflammatory mediators, such as cytokines and chemokines

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When to use 10mg versus 5mg vials A 5mg vial makes more sense during early dose escalation (0.25mg to 0.5mg weekly) because you will use less total peptide over the 28-day reconstitution window

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