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One of the biggest problems it can lead to is low stomach acid (also called hypochlorhydria), which can cause all sorts of downstream issues like poor digestion and nutrient deficiencies

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The concept of synergy between these compounds in human tissue repair is entirely theoretical

To prevent ROS production from semiquinones, the cytosolic, NRF2-regulated flavoproteins NAD(P)H: quinone oxidoreductases (NQOs) and aldo-keto reductase (AKR) can compete with P450 reductases and convert quinones to a relatively stable hydroquinones (quinols) [35]

The compounds FDA approval for specific medical conditions provides regulatory advantage for certain research protocols