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Time-dependent ROC analysis further substantiated the models predictive capacity within this validation cohort, yielding AUC values of 0.612, 0.584, and 0.569 for 1-, 3-, and 5-year survival, respectively (Figure S2C)

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The successful turning point for this dual therapy seems to be the substitution of conventional PPIs with a novel type of PPI, the potassium-competitive acid blocker, vonoprazan, that has a strong and durable inhibitory effect on acid secretion and generates a neutral environment in the stomach, suitable for H

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Intramuscular injection bypasses the digestive system entirely, which may be particularly relevant for patients with gastrointestinal conditions, medication interactions, or nutrient-specific absorption challenges

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GLP-1s and Hormone Therapy For perimenopausal women already using hormone therapy and considering adding GLP-1s, its important to understand how GLP-1s and hormone therapy may interact

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Since GLP-1s are relatively new drugs, their long-term side effects are unknown

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