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Oxidative stress suppresses the expression of these antioxidant defenses, but GSH has been shown to reduce stress markers such as ROS, H 2 O 2 , oxidized glutathione (GSSG), and LPO

Diabetes Res Clin Pract 73: 107-110, 2006

The durability of metabolic benefits after washout, the consequences of chronic pan-ERR activation in heart and kidney, and the potential for tolerance or compensatory network changes require longer studies

Expectations should emphasize body composition changes, metabolic improvements (blood glucose, lipids, inflammation markers), and behavioral shifts rather than dramatic weight reduction