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Restoring Lower Esophageal Sphincter Function Sphincter dysfunction sits at the core of GERD pathophysiology

As described below, ROS may uncouple the eNOS-catalyzed reduction of molecular oxygen from the oxidation of L-arginine, resulting in the paradoxical production of the ROS superoxide anion instead of the reducing NO

The starter dose of 2.5mg is intended primarily to help your body adjust and is not approved as a long-term maintenance dose

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Llansola M, Felipo V