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Immediately after the procedure, the plaque typically becomes palpably softer, reflecting controlled collagen micro-disruption, transient tissue edema, and cytokine-mediated relaxation of the fibrotic matrix

This striking statistic underscores the need to examine the potential connection between hormone imba

FIGURE 3 Overall, most studies indicate that virtually all cells involved in skin repair (fibroblasts, keratinocytes, inflammatory cells, tissue stem cells, and vascular endothelial cells) express both ER and ER and are direct targets of E2 (Matsubara and Matsubara, 2012

These findings are shaping treatment guidelines, encouraging the use of this combination to maximize patient outcomes