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Zorn-Kruppa M, Tykhonova S, Belge G, Diehl HA, Engelke M

Cancer, sunlight and vitamin D

In humans, dietary l-carnitine is converted into the atherosclerosis- and thrombosis-promoting metabolite TMAO via 2 sequential gut microbiotadependent transformations: (a) initial rapid generation of the atherogenic intermediate BB, followed by (b) transformation into TMA via low-abundance microbiota in omnivores, and to a markedly lower extent, in vegans/vegetarians

Preclinical work and early clinical trials indicate preferential intratumoral accumulation, sustained inhibition of topoisomerase I and hypoxia-inducible factor 1 alpha (HIF-1), and downregulation of HIF-1-related markers such as carbonic anhydrase IX in human tumor biopsies [90,91,92]

Auch die Lymphozytenproliferation, die Phagozytoseaktivitt der Granulozyten und Monozyten, sowie die Aktivitt der natrlichen Killerzellen wird durch L-Carnitin gesteigert