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Distribution to injury sites tendon, ligament, muscle is also evidenced by efficacy at those sites

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Second, heterogeneity in inflammatory subtypes may exist among EDC patients, with some individuals exhibiting IL-1 -driven immune responses, while others may show predominance of TNF-, HMGB1, or NLRP3 inflammasome activation

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These events trigger downstream signaling pathways, including AKT, Ras (rat sarcoma), and STAT3 pathways, which are required for MET biological activities (Ponzetto et al., 1994