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Studies have been done on L-Carnitine since 1937

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The most rigorous bone-specific human RCT to date found statistically significant reductions in hip and lumbar spine bone density within 52 weeks in a specific study population

For constipation: Increase fiber intake, drink plenty of water, and consider a fiber supplement or stool softener

"Effect of vitamin K on bone mineral density and fractures in adults: an updated systematic review and meta-analysis of randomised controlled trials"