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Chronic hyperglycemia in diabetes downregulates GIP receptor (GIPR) expression and impairs GIP-mediated insulin secretion [21], rendering high-doses of GIP infusions ineffective [22]

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Making Informed Decisions About GLP-1 Treatment The decision to start a GLP-1 medication should always involve a thorough discussion with your healthcare provider

So, theoretically, it might cross-react with more human antigens