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Therefore, monitoring serum GR activity holds potential clinical value for the auxiliary diagnosis and prognosis of these conditions [38]

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Acetic acid enters the tricarboyxlic acid cycle, and then the transfer of ammonia yields alpha-ketoglutarate, which receives an ammonia donor from a chain of amino acidssuch as leucine, isoleucine, and valineand a variety of amino donors, such as aspartic acid, gamma-aminobutyric acid (GABA), and alanine (Luc and Magistretti, 2004)

However, a radical cure for SUD usually means abstaining from substance abuse and dependence, but relapse is common and a radical cure for such disorders has not yet been discovered

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