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Sun (2021) a Chinese group working with APP/PS1 amyloid-pathology mice showed restoration of spatial learning with oral dosing (1.442.88 mg/kg, 3 months): neuron and synaptophysin counts rose, astrocyte and microglial activation fell, IL-1 and TNF- dropped and anti-inflammatory IL-10 increased

These changes may result in segmental weakness of the artery, predisposing to rupture into the lumen

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This creates additional uncertainty when evaluating both safety and clinical outcomes

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