Centrally acting amphetamine derivatives (desoxyephedrine, phentermine and diethylpropion) were among the earliest pharmacologic agents used for weight loss
While Hamilton, 28, had been on numerous antidepressants when she was a teen, she no longer needs them
The safety argument is equally compelling
Sawicka-Gutaj and colleagues, in International Journal of Obesity (April 2026), pooled 24 trials and concluded GLP-1 RAs deliver "quality" weight loss with relatively preserved lean tissue reductions of approximately 14% in lean body mass across treatment durations from 3 to 12 months
In NRK-52E cells, TGF-1 stimulation considerably upregulated the expression levels of p53 and nuclear Nrf2 protein, which was consistent with the trend of erastin-induced cells and animal models, indicating that Nrf2 is probably related to ferroptosis under diabetic conditions[83]