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Yet the consequences are unknown Bioavailability: there are four specific metabolic steps necessary to convert cyanocobalamin into one of the coenzyme forms, which is a clear metabolic disadvantage (3) Utilisation problems: certain hereditary diseases, as well as metabolic disorders, prevent the conversion of cyanocoalamin into the active B12 forms (4) Steals methyl groups: cyanocobalamin requires a methyl group to convert into methylcobalamin, which it takes from the important amino acid S-adenosylmethionine (SAM)

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Mol Cell Biochem (2010) 343(1-2):16371

Bloomer RJ, Smith WA, Fisher-Wellman KH: Oxidative stress in response to forearm ischemia-reperfusion with and without carnitine administration