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Neuroimaging and cerebrospinal fluid analyses might give us some clues, but more research is needed to identify the right patient populations for these therapies

2009 Feb-Apr;30(1-2):42-59

In a small, open-label phase 2A study in 20 patients with TRD, oral dextromethorphan (45 mg)quinidine (10 mg) improved depression symptoms from baseline, with 45% response and 35% remission rates, although the open-label design and lack of a control arm limit interpretation of the results [107]