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High-altitude exposures and intestinal barrier dysfunction

M.DelvauxE.NolzJ.OlsenG.BerchtoldN.et al (2017)

Specific bacteria and metabolites associated with response to fecal microbiota transplantation in patients with ulcerative colitis - ScienceDirect

The localized accumulation of Cu2+ induces cuproptosis in cancer cells, promotes the release of damage-associated molecular patterns, enhances DC activation - evidenced by a 2.3-fold increase in CD80/CD86 expression - and facilitates increased infiltration of CD8+ T cells (1.8-fold) in murine melanoma models, thereby augmenting anti-tumor immune responses