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Multiple regression analysis identified that 1) eGFR at the time of drug addition, 2) change in HbA1c from at the time of drug addition to the final observation, and 3) the preceding of SGLT2i were independent and significant determinants of eGFR decline

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The gap between expectation and reality comes down to three things most guides never mention: injection technique matters more than formulation purity, side effects cluster in the first 72 hours, and nearly all adverse reactions are dose-dependent rather than compound-specific