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Increased expression of IL-37 in patients with Graves disease and its contribution to suppression of proinflammatory cytokines production in peripheral blood mononuclear cells

This metabolic perturbation significantly downregulates the expression of intestinal tight junction proteins, particularly ZO-1 (Mishra et al., 2023), thereby initiating a multistep pathogenic cascade: (i) compromised intestinal barrier integrity promotes bacterial translocation and systemic dissemination of deleterious metabolites

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